The Mother Machine of Cell Therapy

A cell intelligent-manufacturing laboratory with its own patented mother machine — pharmaceutical-grade exosome products, 500-unit pilots, weeks not quarters, every batch documented.

Request a Quote
What we do

Real manufacturing, not re-bottling — our own seed bank, patented mother machine, and 43,000 storage slots under one roof

Shelf-ready, because the file chain is complete — FDA DMF and INCI filings, drafted standards, a full-panel COA in every box

500 units to start, weeks to deliver — pilots and production on one validated line, 30,000+ units shipped when it hits

43,000
liquid-nitrogen storage slots
seed bank capacity
22,554
cargo knowledge entries
+ 3,048 donor samples · 4,824 process records
~93%
candidate seeds screened out by AI scoring
0–100 scoring · ≈7% admitted
10,000+
treatment sessions delivered
internal observational data
18 · 50+
hospitals · regional chains
hero SKU: 30,000+ units in 3 months
01.
AI Seed Intelligence
22,554 cargo knowledge base entries on file; AI scoring rejects ~93% of candidate seeds, advancing only ~7% into process development.
02.
NuoqTFF 1.0 Mother Machine
0.5–5 L fully closed micro-batches; prescription to vial in hours, with zero exposure at any point.
03.
Compliant Delivery Ecosystem
National standard drafting member · INCI 41316 · FDA DMF 044197 · delivery network of 18 hospitals and 50+ chains — anchored in standards and filings.
Proof, not promises

They already ship on the mother machine.

Case library →
Case 01 · ExoScalp™

Scalp program, 90-day documented window

Monthly cadence from a network clinic — the record that became the standard program design.
Channel case · Model B

Hero SKU: 30,000+ units in 3 months

Mother-and-baby channel launch on a documented micro-batch chain — 60% repeat purchase.
Documents, not claims

Every capability traces to a filing

FDA DMF · INCI · standards drafting · PICC insurance — inspect them on the qualifications page.

Individualized EV therapy, industrially made – 

exobreath line packaging3 designs
INHALED
ExoBreath™
Inhaled EV nebulization line with a patented nebulizing device for respiratory-wellness programs
exomatr line packaging3 designs
TOPICAL
ExoMatr™
Matrix-modified EV particles and hydrogels for barrier-companion gels and creams
accucrystal line packaging3 designs
INJECTION
AccuCrystal™
miR-204-enriched precision EVs for professional-administration clinic programs
rejuvasilk line packaging5 designs
SKINCARE
RejuvaSILK™
Lyophilized EV powder, patch masks, and rose-derived plant EVs — the mass-retail workhorse line
trisleep line packaging3 designs
ORAL
TriSleep™
Fermented marine-derived EVs + plant EXO quick-dissolve tablets on food-function filing routes
precision-microcrystal line packaging3 designs
DELIVERY
Precision Microcrystal™
Acupoint microcrystal suspension with matched carriers for guided targeted delivery
exomist line packaging3 designs
EYECARE
ExoMist™
Single-dose EV drops and fine mists for screen-fatigue and eye-comfort programs
dermfix line packaging4 designs
PROFESSIONAL
DermFix™
Clinic-channel point-care and repair formats for aesthetics and dermatology practices
oralbio line packaging6 designs
ORAL
OralBio™
Segment-specific EV softgels and liquids on blue-hat and cross-border filing routes
acucrystal line packaging3 designs
TOPICAL
AcuCrystal™
Joint- and shoulder-comfort patches with sustained-release EV delivery
exoscalp line packaging4 designs
SCALP
ExoScalp™
Scalp mists and soothing essences for scalp-balance rituals and clinic programs
exofem line packaging4 designs
WOMENS
ExoFem™
Intimate-care mists and stage-specific oral pairings for women's programs
expet line packaging4 designs
ANIMAL
ExoPet™
Joint, skin, and oral-wellness programs for aging dogs and cats, veterinary-channel first
National Standard, Exosome Particle Size & Concentration Measurement Guidelines — 2026 No.17National standard · Drafting member
T/CAPS 031–2025Association standard
T/CEAC 044–2024Association standard
T/CIET 413–2024Association standard
T/CEAC 111–2025Association standard
INCI 41316INCI name
FDA DMF 044197Drug Master File
40+ patentsPatent portfolio
Newsroom
View all news
Milestones
INCI 41316 + FDA DMF 044197 dual filings completed
View newsroom
Milestones
Delivery network reaches 18 hospitals and 50+ chains
View newsroom
Milestones
TONGNIAN founded on 4 documented cell banks and 2,000+ samples
View newsroom
The Nucleus · AI Agent (coming soon)

Ask the EV data brain — every answer carries a citation.

The Nucleus is TONGNIAN's cargo data brain: questions on EV manufacturing, specifications, standards, and filings — answered with citations. Access opens soon; in the meantime, start with our whitepapers and knowledge hub.

Preview The Nucleus